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U Urtica dioica

Urtica dioica

Taxonomy:

Kingdom : Plantae

Division : Magnoliophyta

Class : Magnoliopsida

Order : Rosales

Family : Utricaceae

Genus : urtica

Chemical Composition:

Structurally elucidated compoundas from the lipophilic fraction include sterines, triterpenic acid, coumarins, simple phenols, lignans, ceramides and hydroxyl fatty acids. Flavonol glycosides, chlorophyll α and β, coproporphyrin, β carotene, 5-hydroxy tryptamine,nicotine, threono-1,4-lactone, formic, citric, butyric, p-coumaric, succinic and threonic acids. Galacturonic acid. Kaempferol, isorhamnatin, quercetin. Serine-Ogalactoside. Se, Mn, Fe, Mg,histamine, formic acid, acetylcholine, acetic acid, butyric acid, leukotrienes, 5-hydroxytryptamine ,very high in vitamin K (more K1), iron, calcium, sulfur, sodium,copper, manganese, chromium, and silicon, iron, calcium, sulfur, sodium, copper, manganese,

chromium, vitamins A and C, iron, calcium, magnesium, potassium and chlorophyll, agglutinin, beta-sitosterol, carotenoids: beta-carotene, xanthophylls, chlorophyll, enzymes , flavonoids, including glycosides of quercetin, kaempferol and rhamnetin, glucoquinone: possibly hypoglycemic,isolectins, minerals: iron, selenium,nettle poison: Found in the stinging hairs of the plant, this is made up of formic acid, histamine, a resinic acid-like substance and volatile acids, oleanolic acid, polysaccharides, scopoletin, tannins, caffeic malic acid: anti-inflammatory, vitamins: B,complex , silicon , p-hydroxylbenzalcohol, Dotriacotane,erucic acid, scopoletin, rutin and p-hydroxylbenzalcohol

Part used : Leaves(stinging hairs)

Reference:

Chemical Constitutes:

Studies on the chemical constituents of Urtica dioica L. grown in Tibet Autonomous Region.

        http://www.ncbi.nlm.nih.gov/pubmed/17918434

              http://www.theherbprof.com/hrbNettle.htm

              http://findarticles.com/p/articles/mi_m0FDN/is_/ai_n27421822

              http://www.viable-herbal.com/Singles/herbs/s440.htm

              http://books.google.co.in/books?id=AoWtF1ruQJsC&pg=PA25&lpg=PA25&dq=

     Urtica+dioica+chemical+constituents&source=web&ots=UZclx1Z9KE&sig=Hfo9t6WvtKHZ5NxKA_

              ufmhGxYq8&hl=en&sa=X&oi=book_result&resnum=6&ct=result#PPA28,M1

              http://www.actahort.org/members/showpdf?booknrarnr=597_12

              http://books.google.co.in/books?id=AoWtF1ruQJsC&pg=PA25&lpg=PA25&dq=

             Urtica+dioica+chemical+constituents&source=web&ots=UZclx1Z9KE&sig=

             Hfo9t6WvtKHZ5NxKA_ufmhGxYq8&hl=en&sa=X&oi=book_result&resnum=6&ct=result#PPA28,M1

              http://www.bastyr.edu/academic/botmed/urtica_dioica.asp

              http://www.actahort.org/members/showpdf?booknrarnr=597_12

Anti-hyperglycemic activity:

Maintaining a physiological blood glucose level with 'glucolevel', a combination of four anti-diabetes plants used in the traditional arab herbal medicine.

http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2586306&blobtype=pdf

The granule cell density of the dentate gyrus following administration of Urtica dioica extract to young diabetic rats.

              www.ncbi.nlm.nih.gov/pubmed/18828102

New phytotherapical opportunity in the prevention and treatment of 2-type of diabetes mellitus]

             www.ncbi.nlm.nih.gov/pubmed/17575800

Medicinal plants used in Kirklareli Province (Turkey).

             www.ncbi.nlm.nih.gov/pubmed/17257791

             The use of medicinal herbs by diabetic Jordanian patients.

www.ncbi.nlm.nih.gov/pubmed/17182483

Screening of herbal extracts for activation of the human peroxisome proliferator-activated receptor.

www.ncbi.nlm.nih.gov/pubmed/17152989

Inhibition of alpha-glucosidase by aqueous extracts of some potent antidiabetic medicinal herbs.

www.ncbi.nlm.nih.gov/pubmed/1 5704495

Antihyperglycemic activity of the aqueous extract of Urtica dioica.

www.ncbi.nlm.nih.gov/pubmed/14630172

Induction of insulin secretion by a component of Urtica dioica leave extract in perifused Islets of Langerhans and its in vivo effects in normal and streptozotocin diabetic rats.

www.ncbi.nlm.nih.gov/pubmed/14522431

Glutathione S-transferases and malondialdehyde in the liver of NOD mice on short-term treatment with plant mixture extract P-9801091.

www.ncbi.nlm.nih.gov/pubmed/12722130

Hypoglycemic activity of Urtica pilulifera in streptozotocin-diabetic rats.

www.ncbi.nlm.nih.gov/pubmed/12648821

Effect of 'antidiabetis' herbal preparation on serum glucose and fructosamine in NOD mice.

www.ncbi.nlm.nih.gov/pubmed/11297848

Phytotherapy of hypertension and diabetes in oriental Morocco .

www.ncbi.nlm.nih.gov/pubmed/9324004

Glycaemic effects of traditional European plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice.

www.ncbi.nlm.nih.gov/pubmed/2743711

Identification of antidiabetic effect of iridoid glycosides and low molecular weight polyphenol fractions of Corni Fructus, a constituent of Hachimi-jio-gan, in streptozotocin-induced diabetic rats.

http://www.ncbi.nlm.nih.gov/pubmed/17603169

Beneficial effect of Corni Fructus, a constituent of Hachimi-jio-gan, on advanced glycation end-product-mediated renal injury in Streptozotocin-treated diabetic rats.

http://www.ncbi.nlm.nih.gov/pubmed/17329849

Corni fructus as the major herb of Die-Huang-Wan for lowering plasma glucose in Wistar rats.

http://www.ncbi.nlm.nih.gov/pubmed/15525452

Corni fructus scavenges hydroxy radicals and decreases oxidative stress in endothelial cells.

http://www.ncbi.nlm.nih.gov/pubmed/17201652

Identification of antidiabetic effect of iridoid glycosides and low molecular weight polyphenol fractions of Corni Fructus, a constituent of Hachimi-jio-gan, in streptozotocin-induced diabetic rats.

http://www.ncbi.nlm.nih.gov/pubmed/17603169

Beneficial effect of Corni Fructus, a constituent of Hachimi-jio-gan, on advanced glycation end-product-mediated renal injury in Streptozotocin-treated diabetic rats.

http://www.ncbi.nlm.nih.gov/pubmed/17329849

Corni fructus as the major herb of Die-Huang-Wan for lowering plasma glucose in Wistar rats.

http://www.ncbi.nlm.nih.gov/pubmed/15525452

Corni fructus scavenges hydroxy radicals and decreases oxidative stress in endothelial cells.

http://www.ncbi.nlm.nih.gov/pubmed/17201652