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Diabetes is a chronic health condition in
which the body is either unable to produce insulin, produces
too little insulin, or becomes resistant to insulin, resulting
in the improper breakdown of sugar (glucose). As a
result blood sugar levels rise to a dangerous level.
It is a serious condition that needs
controlling and maintaining to avoid complications
Description
When a person eats sugars and starches,
the body changes them rapidly into a sugar called glucose.
Glucose
is the main source of body energy. Your liver produces
some glucose and you get the rest through the above
digestion process. It is absorbed from the intestine and
is metabolized and used immediately where it is needed by
all cells in the body via glucose transportation, and the
rest is stored in the muscles and liver as glycogen for
future requirement.
In diabetes, the mechanism that controls the amount of
glucose in the blood breaks down. The blood glucose level
rises to dangerously high levels as a result, causing
symptoms and damage to the body.
Glucose is transported by a signal produced by insulin.
After transportation insulin triggers its correct
dispersion.
Insulin is a
hormone (part of the endocrine system) produced by beta
cells (islets of Langerhans) in the pancreas. It manages
how much glucose the liver produces and helps glucose to
be taken up by the cells where it is used as energy.
Insulin acts as a key to unlock the cells so that blood
sugar can be stored in them. High blood sugar levels can
be related to not enough keys (insulin), or an inefficient
lock (cell entry point), or both.
Diabetes
is actually a group of diseases characterized by high
levels of blood glucose resulting from defects in insulin
production, insulin action, or both, resulting in either hypo-
(abnormally low blood sugar) or hyperglycaemia (an elevated
concentration of glucose in the blood).
The primary types of diabetes include type 1 diabetes and type
2 diabetes.
Type 1 diabetes
develops when the body’s immune system destroys
pancreatic beta cells, the only cells in the body that make
the hormone insulin that regulates blood glucose. It occurs
most usually from childhood or teen years.
Type
2 diabetes consists of a resistance to insulin
produced by the body. Obesity is a heavy contributor to its
development, as is type 1 diabetes and high (imbalanced)
cholesterol levels.
Insulin resistance occurs when the body fails to respond
effectively to the insulin already produced by the pancreatic
beta cells.
Type 2 diabetes usually affects adults following a trigger.
This could be another illness or the effects of obesity, for
example.
Other forms of diabetes
Gestational diabetes is a form of glucose
intolerance diagnosed during pregnancy where a woman is not
able to increase their secretion of insulin. Gestational
diabetes requires treatment to normalize maternal blood
glucose levels to avoid complications in the fetus. Genetics
and obesity are major contributing factors.
Gestational diabetes is usually asymptomatic and not
necessarily life threatening to the mother. This condition is
associated with an increase in neonatal morbidity, neonatal
hypoglycaemia and jaundice.
It is characterized by excessive hunger, thirst, and the need
to urinate, it is a mild condition and often goes unnoticed,
but it is important to treat because elevated blood sugar
levels can damage the fetus.
It has been found to respond well, and even to resolve, with a
combination of diet, exercise and appropriate supplementation
where necessary.
Secondary diabetes is named due to it forming
as a result of other particular conditions, such as pancreatic
disease, hormone disturbances, drug overuse and malnutrition.
Impaired glucose tolerance is a condition
that shows blood glucose levels that are intermediate between
normal and clearly abnormal.
Diabetes is often under diagnosed, being more likely to be
recorded as one of the major complications of circulatory
problems and heart disease (arthersclerosis, stroke, or high
blood pressure), kidney disease, retinopathy (damage to the
retina), blindness, nerve damage and even foot ulcers (heart
attacks and strokes are more common in diabetics due to the
increased risk of clogging of blood vessels). Diabetic skin
lesions are also a possible long term effect.
In all forms of diabetes, high levels of blood glucose
increase the risk of the above, what are now known to be
diabetes-related complications (rather than diseases in their
own right).
Diabetic retinopathy is a damage to the retina of the
eye that can eventually lead to blindness. It often has no
early warning signs. In general however, a person is likely to
notice blurred vision, which in some cases will get worse
during the day.
As new blood vessels form at the back of the eye as a part of proliferative
diabetic retinopathy (PDR) process they can bleed and
further blur vision. In extreme cases a person may only be
able to tell light from dark in that eye.
These conditions are
also multi-generating, i.e. it has been proven that high blood
pressure and high levels of blood glucose can themselves
increase the risk of a person with diabetes progressing to
other severe, potentially fatal complications such as kidney
failure.
People with diabetes
have an increased mortality rate due to all these consequent
complications.
Left untreated (or undiagnosed), or mismanaged diabetes can
easily lead to any or all of these long-term damages and major
organ failures.
Further Type 1 and type 2 complications
Other complications related to immunity depletion include
ulcers, gastrointestinal disorders, genitourinary and sexual
dysfunctions. Complications with both type I and II occur when
blood sugar levels are not properly controlled. Ketoacidosis
(not taking enough insulin, allowing glucose to build up in
the blood), and hyperosmolar nonketogenic coma (severe
dehydration) are examples.
Complications can be acute and chronic. People with diabetes
can suffer both high and low blood sugar episodes. Acute
conditions resulting from one or either form of diabetes
include:
Hypoglycaemia (or dangerously low blood
sugar) and
Hyperglycaemia (or dangerously high blood
sugar).
These are both life-threatening and need to be managed and
maintained.
Statistics
Over 194 million people suffer with diabetes
worldwide. This global figure is estimated to reach 333
million by 2025 if current trends continue. This includes:
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Around 18.2 million diagnosed Americans;
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Approximately 1.8 million diagnosed in
the UK;
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18.1 diagnosed in India;
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10.3 million diagnosed in China; and
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13 million diagnosed in other Asian and
island areas
Interestingly diabetes is more prevalent
amongst black and Hispanic origins than in white people of
all age groups. For those 65 years and older prevalence is
greater across the board.
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